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KMID : 0378019700130010116
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New Medical Journal
1970 Volume.13 No. 1 p.116 ~ p.124
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Experimental Studies on Bacteriemia and Bacteriuria in Rabbits
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Abstract
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There have been numerous reports concerning the fates of microbes introduced into the new host tissues and many factors, which might effect the outcome of the host-parasite interactions have been postulatted. It is also known that there are the phenomena of organ specificities in establishimg the infections due to certain microbes.
The author conceived of an experiments to study the outcome of the introduction of a few species of bacteria, singly or together with, into the rabbit veins, by following the viable number of the organisms in the blood and urine of the infected animals.
Thus, cultures of Staph. aureus, Es. coli and Ps. aeruginosa, viable units of each speces being 3X10´, 7X10´ and 9X10´ respectively, were inoculated intravenously into the ear veins of rabbits. After 3 hours and 1, 2, 3, 4, 6, 7, 10, 14, 17, and 21 days of infections, heart blood and urine were taken aseptically and viable number of organisms were determined by cultivating serial dilutions of the specinens.
The results might be summarized as follows:
1. Staph. aureus, Es. coli, and Ps. aeruginosa, whether inoculated singly or together with, appeared to have been removed rapidly from the blood stream.
2. When inoculated singly, the viable number of Staph. aureus in rabbit urine increased rapidly and markedly and reached the peak after 24 hours of infection. Afterwards, begining around after 4 days of infections, the number decreased slowly.
3. Es. coli, inoculated singly, seemed to persist in the urinary tract, without significant increase or decrease in the urine.
4. When inoculated singlly, the number of viable Ps. aeruginosa in the urine increased and decreased rather slowly, their moderate peak being around after 7 days of infections.
5. When inoculated with Es. coli, and Ps. aeruginosa, the number of vialbe Staph. aureus in the urine increased rapidly and markedly and reached the peak after 24 hours of infections. The number continued to be large up until after 14 days of infections and after that decreased slowly.
6. When inoculated with Staph. aureus and Ps. aeruginosa, the number of viable Es. coli in the urine seemed to decrease more markedly than the cases of single infection, except one apparent case of mixed infection with Staph. aurcus.
7. When inoculated with Staph. aureus and Es. coli, the number of viable Ps. aeruginosa in the urine decreased without any significant increase.
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